Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W7VG
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| Former ID |
DCL000423
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| Drug Name |
AMG 108
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| Drug Type |
Small molecular drug
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Discontinued in Phase 2 | [1] | |
| Company |
Amgen
|
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| Structure |
 |
Download2D MOL |
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| Canonical SMILES |
C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
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| PubChem Compound ID | ||||
| PubChem Substance ID |
820339, 824927, 829471, 854455, 854458, 7888374, 11532495, 14774821, 15392822, 24770619, 24770621, 24770665, 36887500, 46391523, 46391948, 46392657, 46394112, 46394113, 46530883, 47208247, 49689710, 57404625, 77434485, 85856193, 103500429, 104077585, 104632275, 117682608, 134338803, 134339052, 134340118, 135020342, 135675084, 137042995, 141755560, 144080329, 160644592, 160779316, 165245606, 180372225, 186024301, 198952847, 224718993, 226820362, 241051921, 243906436, 252166484
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 1 receptor type 2 (IL1R2) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | MAPK signaling pathway | |||
| Cytokine-cytokine receptor interaction | ||||
| Hematopoietic cell lineage | ||||
| Amoebiasis | ||||
| HTLV-I infection | ||||
| Transcriptional misregulation in cancer | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| Pathway Interaction Database | IL1-mediated signaling events | |||
| Reactome | Interleukin-1 signaling | |||
| WikiPathways | MAPK Signaling Pathway | |||
| Interleukin-1 signaling | ||||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020487) | |||
| REF 2 | Clinical pipeline report, company report or official report of Amgen (2009). | |||
| REF 3 | Inflammatory molecules: a target for treatment of systemic autoimmune diseases. Autoimmun Rev. 2007 Nov;7(1):1-7. | |||
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