Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W7IR
|
|||
| Former ID |
DIB011380
|
|||
| Drug Name |
DMP-543
|
|||
| Synonyms |
XR-543
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Discontinued in Phase 2 | [1] | |
| Company |
Bristol-Myers Squibb Pharma Co
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C26H18F2N2O
|
|||
| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC(=NC=C4)F)CC5=CC(=NC=C5)F
|
|||
| InChI |
1S/C26H18F2N2O/c27-23-13-17(9-11-29-23)15-26(16-18-10-12-30-24(28)14-18)21-7-3-1-5-19(21)25(31)20-6-2-4-8-22(20)26/h1-14H,15-16H2
|
|||
| InChIKey |
MUJBUUDUXGDXLW-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 160588-45-4
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:93560
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv7 (KCNQ) | Target Info | Modulator | [2] |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | |||
| Cholinergic synapse | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Protein digestion and absorption | ||||
| Vibrio cholerae infection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009278) | |||
| REF 2 | KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.Pharmacol Res.2011 Oct;64(4):397-409. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.