Drug Information
Drug General Information | Top | |||
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Drug ID |
D0W2KL
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Drug Name |
PMID28394193-Compound-37
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C27H34F2N4O3
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Canonical SMILES |
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)C(C)C4CCN(CC4)CC(F)F)C)OC
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InChI |
1S/C27H34F2N4O3/c1-16-13-23(36-4)21(26(34)31-16)14-30-27(35)25-18(3)33(22-8-6-5-7-20(22)25)17(2)19-9-11-32(12-10-19)15-24(28)29/h5-8,13,17,19,24H,9-12,14-15H2,1-4H3,(H,30,35)(H,31,34)
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InChIKey |
RQOXQFWLPWTPPB-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Enhancer of zeste homolog 2 (EZH2) | Target Info | Inhibitor | [1] |
Target's Patent Info | Enhancer of zeste homolog 2 (EZH2) | Target's Patent Info | [1] | |
KEGG Pathway | MicroRNAs in cancer | |||
NetPath Pathway | IL2 Signaling Pathway | |||
Reactome | PRC2 methylates histones and DNA | |||
Oxidative Stress Induced Senescence | ||||
PKMTs methylate histone lysines | ||||
WikiPathways | Interactome of polycomb repressive complex 2 (PRC2) | |||
Endoderm Differentiation | ||||
Integrated Pancreatic Cancer Pathway | ||||
Histone Modifications | ||||
Cell Differentiation - meta | ||||
miRs in Muscle Cell Differentiation | ||||
miR-targeted genes in muscle cell - TarBase | ||||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in epithelium - TarBase |
References | Top | |||
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REF 1 | EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. |
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