Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W1VL
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| Former ID |
DNC006586
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| Drug Name |
N-(naphthalen-1-yl)-4-phenylthiazol-2-amine
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| Synonyms |
CHEMBL208452; N-(naphthalen-1-yl)-4-phenylthiazol-2-amine; AC1N24LJ; BDBM50183105; AKOS001583269; EU-0001073; N-naphthalen-1-yl-4-phenyl-1,3-thiazol-2-amine; SR-01000396392
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H14N2S
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| Canonical SMILES |
C1=CC=C(C=C1)C2=CSC(=N2)NC3=CC=CC4=CC=CC=C43
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| InChI |
1S/C19H14N2S/c1-2-8-15(9-3-1)18-13-22-19(21-18)20-17-12-6-10-14-7-4-5-11-16(14)17/h1-13H,(H,20,21)
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| InChIKey |
JWZVJRBKXQFLBH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-C chemokine receptor type 4 (CCR4) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Viral carcinogenesis | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. | |||
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