Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W1MU
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| Former ID |
DIB004682
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| Drug Name |
TBC-M4
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| Synonyms |
MVA-based HIV subtype C vaccine, IAVI; Modified vaccinia Ankara-based HIV subtype C vaccine, International AIDS Vaccine Initiative
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| Drug Type |
Vaccine
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Phase 1 | [1] | |
| Company |
National Institute of Cholera and Enteric Diseases
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) | Target Info | . | [2] |
| Human immunodeficiency virus GAG protein (HIV gag) | Target Info | . | [2] | |
| Reactome | Uncoating of the HIV Virion | |||
| Budding and maturation of HIV virion | ||||
| Integration of provirus | ||||
| Early Phase of HIV Life Cycle | ||||
| Minus-strand DNA synthesis | ||||
| Plus-strand DNA synthesis | ||||
| 2-LTR circle formation | ||||
| Binding and entry of HIV virion | ||||
| Membrane binding and targetting of GAG proteins | ||||
| Assembly Of The HIV Virion | ||||
| Integration of viral DNA into host genomic DNA | ||||
| Autointegration results in viral DNA circles | ||||
| APOBEC3G mediated resistance to HIV-1 infection | ||||
| Vpr-mediated nuclear import of PICs | ||||
| WikiPathways | Host Interactions of HIV factors | |||
| HIV Life Cycle | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00902824) Safety and Immunogenicity of TBC-M4, a MVA HIV Vaccine Alone or in a Prime-Boost Regimen With ADVAX DNA HIV Vaccine. U.S. National Institutes of Health. | |||
| REF 2 | A Phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C-modified vaccinia Ankara virus vaccine candidate in Indian volunteers. AIDS Res Hum Retroviruses. 2009 Nov;25(11):1107-16. | |||
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