Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W1DI
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| Former ID |
DIB015316
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| Drug Name |
AS-1670542
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| Synonyms |
AVATROMBOPAG; 570406-98-3; AKR-501; UNII-3H8GSZ4SQL; 3H8GSZ4SQL; AKR 501; Avatrombopag [USAN:INN]; Doptelet; AS 1670542; Avatrombopag (USAN/INN); GTPL9953; DTXSID30205667; ZINC72190218; AKOS027323962; CS-3397; HY-13463; FT-0728753; D10306; AS1670542
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| Drug Type |
Small molecular drug
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| Indication | Thrombocytopenia [ICD-11: 3B64] | Approved | [1] | |
| Idiopathic thrombocytopenic purpura [ICD-11: 3B64.10; ICD-10: D69.3; ICD-9: 287.31] | Phase 3 | [2] | ||
| Company |
Dova Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C29H34Cl2N6O3S2
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| Canonical SMILES |
C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
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| InChI |
1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)
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| InChIKey |
OFZJKCQENFPZBH-UHFFFAOYSA-N
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| CAS Number |
CAS 570406-98-3
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| PubChem Compound ID | ||||
| ADReCS Drug ID | BADD_D02497 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thrombopoietin receptor (MPL) | Target Info | Agonist | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| WikiPathways | Platelet Aggregation (Plug Formation) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
| REF 2 | ClinicalTrials.gov (NCT01433978) A Phase 3, Multicenter, Randomized, Double-blind, Active-controlled, Parallel-group Trial With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Oral E5501 Versus Eltrombopag, in Adults With Chronic Immune Thrombocytopenia (Idiopathic Thrombocytopenic Purpura). U.S. National Institutes of Health. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). | |||
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