Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W0VD
|
|||
| Former ID |
DCL000494
|
|||
| Drug Name |
Beta-Lapachone
|
|||
| Synonyms |
ARQ 501; SL 11001; A-lapachone; LAPACHONE, BETA; AK-693/21096016; 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione; 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione; 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-B]pyran-5,6-dione
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1] | |
| Company |
Roche
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C15H14O3
|
|||
| Canonical SMILES |
CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C
|
|||
| InChI |
1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
|
|||
| InChIKey |
QZPQTZZNNJUOLS-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 4707-32-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
12553, 87198, 494711, 611544, 5669163, 8152448, 11111370, 11121371, 11121851, 11362440, 11365002, 11367564, 11370151, 11370152, 11373165, 11375726, 11414054, 15196477, 17405278, 24278512, 26753601, 29222999, 47365325, 47440387, 47589107, 47959891, 48110573, 48259373, 49996523, 50106535, 50106536, 50106537, 50106538, 53777823, 53788397, 57322036, 68530614, 79051855, 85087200, 85231108, 90340897, 91708861, 92304299, 92309722, 99300636, 99302154, 103178327, 103852913, 104304799, 117597465
|
|||
| ChEBI ID |
CHEBI:10429
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Escherichia coli Nissle 1917
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Effect | Decrease activity | |||
| Description | Beta-Lapachone can be metabolized by Escherichia coli Nissle 1917, which results in the decrease of the drug's activity. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Modulator | [1] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cancer therapy with beta-lapachone. Curr Cancer Drug Targets. 2002 Sep;2(3):227-42. | |||
| REF 2 | Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep. 2015 Sep 29;5:14554. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.