Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0VO5S
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| Former ID |
DIB000054
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| Drug Name |
LY-2584702
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| Synonyms |
LY-S6K1; LY-S6K1 HCl; LY-S6K1 tosylate; P70 S6 kinase inhibitor (cancer), Eli Lilly
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1], [2] | |
| Company |
Eli Lilly & Co
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| Structure |
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Download2D MOL |
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| Formula |
C21H19F4N7
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| Canonical SMILES |
CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F
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| InChI |
1S/C21H19F4N7/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30)
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| InChIKey |
FYXRSVDHGLUMHB-UHFFFAOYSA-N
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| CAS Number |
CAS 1082949-67-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ribosomal protein S6 kinase (S6K) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8248). | |||
| REF 2 | ClinicalTrials.gov (NCT01241461) A Study of LY2584702 in Solid Tumors. U.S. National Institutes of Health. | |||
| REF 3 | A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.Eur J Cancer.2014 Mar;50(5):876-84. | |||
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