Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0VG0D
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| Former ID |
DCL001085
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| Drug Name |
BEZ235
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| Synonyms |
BEZ-235; S14-0511; NVP-BEZ-235; NVP-BEZ235, BEZ235; 2-(4-(2,3-dihydro-3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1], [2] | |
| Company |
Novartis
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| Structure |
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Download2D MOL |
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| Formula |
C30H23N5O
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| Canonical SMILES |
CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
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| InChI |
1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
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| InChIKey |
JOGKUKXHTYWRGZ-UHFFFAOYSA-N
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| CAS Number |
CAS 915019-65-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
17429886, 24492445, 26746658, 37427121, 53799241, 57378099, 64607901, 75067558, 81043439, 93103165, 99431773, 99460876, 103905146, 112379021, 118847193, 124451892, 124756931, 124898663, 124898664, 124898665, 124898666, 125163738, 125334062, 126643456, 126724121, 127341930, 127341931, 131407083, 131465102, 134339478, 134964397, 135267379, 135631955, 135685270, 135685271, 135685287, 135697736, 135727413, 136024146, 136368052, 136920355, 136920478, 137192289, 140924932, 143452908, 143498077, 144115700, 152240026, 152258809, 152344011
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| ChEBI ID |
CHEBI:71952
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7950). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026094) | |||
| REF 3 | The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia. 2012 Jan;14(1):34-43. | |||
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