Drug Information
Drug General Information | Top | |||
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Drug ID |
D0VA5V
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Former ID |
DNC003639
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Drug Name |
18-methoxycoronaridinate 2-Hydroxyethylamide
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Synonyms |
18-methoxycoronaridinate 2-Hydroxyethylamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C23H31N3O3
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Canonical SMILES |
COCCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)NCCO
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InChI |
1S/C23H31N3O3/c1-29-11-7-16-12-15-13-23(22(28)24-8-10-27)20-18(6-9-26(14-15)21(16)23)17-4-2-3-5-19(17)25-20/h2-5,15-16,21,25,27H,6-14H2,1H3,(H,24,28)/t15?,16-,21-,23+/m0/s1
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InChIKey |
RPYHLEHPZWHJIE-NVVKDKPXSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Neuronal acetylcholine receptor beta-4 (CHRNB4) | Target Info | Inhibitor | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Cholinergic synapse | ||||
Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
Nicotine pharmacodynamics pathway | ||||
Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Highly calcium permeable nicotinic acetylcholine receptors | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Nicotine Activity on Chromaffin Cells |
References | Top | |||
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REF 1 | Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. |
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