Drug Information
Drug General Information | Top | |||
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Drug ID |
D0V8AG
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Former ID |
DNCL002577
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Drug Name |
Poly-ICLC
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Drug Type |
Small molecular drug
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Indication | Glioblastoma multiforme [ICD-11: 2A00.0; ICD-9: 191] | Phase 2 | [1] | |
Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [2] | ||
Recurrent glioblastoma [ICD-11: 2A00.00; ICD-10: C71] | Phase 1/2 | [2], [3] | ||
Company |
Oncovir
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Structure |
Download2D MOL
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Formula |
C26H43N9O21P2
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Canonical SMILES |
C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O.C(CCNC(=O)O)CN.C(C(=O)O)O
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InChI |
1S/C10H13N4O8P.C9H14N3O8P.C5H12N2O2.C2H4O3/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;6-3-1-2-4-7-5(8)9;3-1-2(4)5/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);7H,1-4,6H2,(H,8,9);3H,1H2,(H,4,5)
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InChIKey |
MRYYMYCQXMFJNE-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Toll-like receptor 3 (TLR3) | Target Info | Inducer | [1] |
KEGG Pathway | Toll-like receptor signaling pathway | |||
Hepatitis C | ||||
Hepatitis B | ||||
Influenza A | ||||
Herpes simplex infection | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Toll receptor signaling pathway | |||
Pathway Interaction Database | Endogenous TLR signaling | |||
Reactome | Ligand-dependent caspase activation | |||
MyD88-independent TLR3/TLR4 cascade | ||||
Trafficking and processing of endosomal TLR | ||||
RIP-mediated NFkB activation via ZBP1 | ||||
TRIF-mediated programmed cell death | ||||
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
IKK complex recruitment mediated by RIP1 | ||||
TRAF6 mediated induction of TAK1 complex | ||||
WikiPathways | Toll-like receptor signaling pathway | |||
Cytosolic sensors of pathogen-associated DNA | ||||
Toll-Like Receptors Cascades | ||||
MyD88-independent cascade | ||||
Trafficking and processing of endosomal TLR | ||||
Regulation of toll-like receptor signaling pathway |
References | Top | |||
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REF 1 | Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10. | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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