Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0V7IS
|
|||
Former ID |
DIB006846
|
|||
Drug Name |
Pumafentrine
|
|||
Synonyms |
Pumafentrin; BY-343; BYK-33043
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 2 | [1] | |
Company |
ALTANA Pharma AG
|
|||
Structure |
Download2D MOL |
|||
Formula |
C29H39N3O3
|
|||
Canonical SMILES |
CCOC1=C(C=C2C(=C1)C3CN(CCC3N=C2C4=CC=C(C=C4)C(=O)N(C(C)C)C(C)C)C)OC
|
|||
InChI |
1S/C29H39N3O3/c1-8-35-27-15-22-23(16-26(27)34-7)28(30-25-13-14-31(6)17-24(22)25)20-9-11-21(12-10-20)29(33)32(18(2)3)19(4)5/h9-12,15-16,18-19,24-25H,8,13-14,17H2,1-7H3/t24-,25-/m1/s1
|
|||
InChIKey |
CVDXFPBVOIERBH-JWQCQUIFSA-N
|
|||
CAS Number |
CAS 207993-12-2
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Phosphodiesterase 3 (PDE3) | Target Info | Modulator | [2] |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013080) | |||
REF 2 | The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.PLoS One.2013;8(2):e56867. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.