Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V6OA
|
|||
| Former ID |
DNCL002125
|
|||
| Drug Name |
Lurbinectedin
|
|||
| Synonyms |
UNII-2CN60TN6ZS; 497871-47-3; 2CN60TN6ZS; Lurbinectedin [INN]; SCHEMBL16152477; DTXSID30198065; DB12674; CS-6323; HY-16293; J3.652.626B
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Small-cell lung cancer [ICD-11: 2C25.Y] | Approved | [1] | |
| leukaemia [ICD-11: 2A60-2B33; ICD-9: 208.9] | Phase 3 | [2] | ||
| Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Phase 3 | [2] | ||
| Endometrial cancer [ICD-11: 2C76; ICD-9: 182] | Phase 2 | [3] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Phase 2 | [3] | ||
| Company |
PharmaMar
|
|||
| Structure |
 |
Download2D MOL
|
||
| Formula |
C41H44N4O10S
|
|||
| Canonical SMILES |
CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=C(CCN8)C2=C(N9)C=CC(=C2)OC)OCO7)C)OC(=O)C)C(=C1OC)O
|
|||
| InChI |
1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(17)51-6)29-28(26)36-35(53-16-54-36)18(2)34(29)55-19(3)46/h7-8,11,13,25-26,30-31,37,39,42-43,47-48H,9-10,12,14-16H2,1-6H3/t25-,26-,30+,31+,37+,39-,41+/m0/s1
|
|||
| InChIKey |
YDDMIZRDDREKEP-HWTBNCOESA-N
|
|||
| CAS Number |
CAS 497871-47-3
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Inhibitor | [1] |
| Human Deoxyribonucleic acid minor groove (hDNA min) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 | |||
| REF 2 | ClinicalTrials.gov (NCT02421588) Clinical Trial of Lurbinectedin (PM01183) in Platinum Resistant Ovarian Cancer Patients. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.