Drug Information
Drug General Information | Top | |||
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Drug ID |
D0V4IB
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Former ID |
DAP000631
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Drug Name |
Itraconazole
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Synonyms |
Canadiol; Hyphanox; ITCZ; ITZ; Intraconazole; Itraconazol; Itraconazolum; Itrizole; Oriconazole; Orungal; Prokanazol; Sempera; Spherazole; Sporal; Sporanos; Sporanox; Sporonox; Triasporn; Itraconazol [Spanish]; Itraconazole oral solution; Itraconazolum [Latin]; R 51211; Cis-Itraconazole; Itraconazole & Bovine Lactoferrin; Itraconazole & Nyotran; Itrizole (TN); R-51211; Sporanox (TN); Itraconazole & Nyotran(Liposomal Nystatin); Itraconazole (JAN/USAN); Oriconazole, R51211, Sporanox; Itraconazole [USAN:BAN:INN:JAN]; (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one; (1)-cis-4-(4-(4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2,4-dihydro-2-sec-butyl-3H-1,2,4-triazol-3-one; 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-pipera-zinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl); 4-(4-{4-[4-({[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}oxy)phenyl]piperazin-1-yl}phenyl)-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
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Drug Type |
Small molecular drug
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Indication | Fungal infection [ICD-11: 1F29-1F2F; ICD-10: B35-B49; ICD-9: 110-118] | Approved | [1] | |
Therapeutic Class |
Antifungal Agents
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Company |
Janssen Pharmaceutica
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Structure |
Download2D MOL |
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Formula |
C35H38Cl2N8O4
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Canonical SMILES |
CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
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InChI |
1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
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InChIKey |
VHVPQPYKVGDNFY-ZPGVKDDISA-N
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CAS Number |
CAS 84625-61-6
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:6076
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ADReCS Drug ID | BADD_D01217 | |||
SuperDrug ATC ID |
J02AC02
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SuperDrug CAS ID |
cas=084625616
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Interaction between the Drug and Microbe | Top | |||
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The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.82; p = 0.043). | |||
Studied Microbe: Odoribacter splanchnicus
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Odoribacter splanchnicus (log2FC = -1.136; p = 0.034). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Blautia hansenii DSM20583 (log2FC = -1.527; p = 0.034). | |||
Studied Microbe: Blautia luti DSM 14534
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Blautia luti DSM 14534 (log2FC = -0.827; p = 0.017). | |||
Studied Microbe: Clostridium sp.
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Clostridium sp. (log2FC = -1.649; p = 0.049). | |||
Studied Microbe: Clostridium sporogenes ATCC 15579
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -1.204; p = 0.003). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[2] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Itraconazole can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -1.067; p = 0.022). |
Drug Resistance Mutation (DRM) | Top | |||
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DRM | DRM Info |
Target and Pathway | Top | |||
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Target(s) | Candida Cytochrome P450 51 (Candi ERG11) | Target Info | Modulator | [3] |
Hedgehog signaling pathway (HS pathway) | Target Info | Inhibitor | [4], [5] |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076104. | |||
REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 5 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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