Drug Information
Drug General Information | Top | |||
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Drug ID |
D0V2OS
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Former ID |
DIB006379
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Drug Name |
DX-9065
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Synonyms |
DX-9065 (enteric-coated tablet)
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Indication | Coagulation defect [ICD-11: 3B10.0] | Discontinued in Phase 2 | [1], [2] | |
Company |
Daiichi Sankyo Co Ltd
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Target and Pathway | Top | |||
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Target(s) | Coagulation factor Xa (F10) | Target Info | Inhibitor | [3], [4] |
KEGG Pathway | Complement and coagulation cascades | |||
Panther Pathway | Blood coagulation | |||
Pathwhiz Pathway | Coagulation | |||
Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
Reactome | Extrinsic Pathway of Fibrin Clot Formation | |||
Intrinsic Pathway of Fibrin Clot Formation | ||||
Common Pathway of Fibrin Clot Formation | ||||
Gamma-carboxylation of protein precursors | ||||
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
WikiPathways | Complement and Coagulation Cascades | |||
Human Complement System | ||||
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Blood Clotting Cascade | ||||
Formation of Fibrin Clot (Clotting Cascade) |
References | Top | |||
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REF 1 | DX-9065a Daiichi. Curr Opin Investig Drugs. 2003 Sep;4(9):1105-12. | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004028) | |||
REF 3 | Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. | |||
REF 4 | Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49. |
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