Drug Information
Drug General Information | Top | |||
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Drug ID |
D0V1HA
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Former ID |
DNC013433
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Drug Name |
N-hydroxy-3-(naphthalen-1-yl)acrylamide
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Synonyms |
CHEMBL245548; N-hydroxy-3-(naphthalen-1-yl)acrylamide; SCHEMBL14106948; BDBM50207560; (E)-3-(1-Naphthalenyl)-2-propenehydroximic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C13H11NO2
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Canonical SMILES |
C1=CC=C2C(=C1)C=CC=C2C=CC(=O)NO
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InChI |
1S/C13H11NO2/c15-13(14-16)9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-9,16H,(H,14,15)/b9-8+
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InChIKey |
AOXOYUCWJCCUDO-CMDGGOBGSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histone deacetylase 8 (HDAC8) | Target Info | Inhibitor | [1] |
KEGG Pathway | Alcoholism | |||
Viral carcinogenesis | ||||
Panther Pathway | Wnt signaling pathway | |||
Pathway Interaction Database | Signaling events mediated by HDAC Class I | |||
Reactome | NOTCH1 Intracellular Domain Regulates Transcription | |||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
HDACs deacetylate histones | ||||
WikiPathways | Integrated Pancreatic Cancer Pathway | |||
Neural Crest Differentiation | ||||
Cell Cycle |
References | Top | |||
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REF 1 | Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. |
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