Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V0SD
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| Former ID |
DNC004777
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| Drug Name |
2-Morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one
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| Synonyms |
CHEMBL179043; 2-(morpholin-4-yl)-4h-pyrido[1,2-a]pyrimidin-4-one; 17326-31-7; NSC110390; AC1Q6IJU; AC1L6MD6; 2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one; 2-Morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one; SCHEMBL4544196; CTK4D4568; DTXSID80296606; ZINC1702791; BDBM50159642; AKOS024361168; NSC-110390; MCULE-7092692912; ST50991317
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H13N3O2
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| Canonical SMILES |
C1COCCN1C2=CC(=O)N3C=CC=CC3=N2
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| InChI |
1S/C12H13N3O2/c16-12-9-11(14-5-7-17-8-6-14)13-10-3-1-2-4-15(10)12/h1-4,9H,5-8H2
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| InChIKey |
VDMRPNTZWKDYBB-UHFFFAOYSA-N
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| CAS Number |
CAS 17326-31-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | |||
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