Drug Information
Drug General Information | Top | |||
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Drug ID |
D0UV9F
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Former ID |
DIB008580
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Drug Name |
GSK-894281
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Synonyms |
Ghrelin agonists (gastric motility disorder); SB-791016; Ghrelin agonists (gastric motility disorder), GlaxoSmithKline; Ghrelin agonists (gastric motility disorders), GSK
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Drug Type |
Small molecular drug
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Indication | Gastric motility disorder [ICD-11: DA21; ICD-10: K22.4] | Investigative | [1] | |
Company |
GlaxoSmithKline plc
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Structure |
Download2D MOL |
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Formula |
C24H28FN3O4S
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Canonical SMILES |
CC1CN(CC(N1)C)C2=CC(=C(C=C2)OC)NS(=O)(=O)C3=CC(=C(C=C3)C4=CC=C(O4)C)F
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InChI |
1S/C24H28FN3O4S/c1-15-13-28(14-16(2)26-15)18-6-10-24(31-4)22(11-18)27-33(29,30)19-7-8-20(21(25)12-19)23-9-5-17(3)32-23/h5-12,15-16,26-27H,13-14H2,1-4H3/t15-,16+
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InChIKey |
OIWVNMRPHUCLHN-IYBDPMFKSA-N
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CAS Number |
CAS 874958-63-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Growth hormone secretagogue receptor 1 (GHSR) | Target Info | Agonist | [1] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | Leptin Signaling Pathway | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246). |
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