Drug Information
Drug General Information | Top | |||
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Drug ID |
D0UL7R
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Former ID |
DIB020952
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Drug Name |
SKA-31
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Synonyms |
2-aminonaphthiazole; 2-amino-beta-naphthothiazole
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C11H8N2S
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Canonical SMILES |
C1=CC=C2C(=C1)C=CC3=C2N=C(S3)N
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InChI |
1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
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InChIKey |
FECQXVPRUCCUIL-UHFFFAOYSA-N
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CAS Number |
CAS 40172-65-4
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PubChem Compound ID | ||||
PubChem Substance ID |
72267, 3156347, 3896230, 5088516, 6431769, 10226800, 24349684, 44425425, 47194328, 47548093, 48368384, 51887739, 58033031, 72275214, 85163794, 85183726, 88877473, 103840202, 104413886, 104660167, 117521039, 117529682, 117529683, 117529692, 118184128, 125141925, 125410769, 127833635, 130917154, 131290352, 131351698, 135050694, 135651046, 137014460, 143407326, 144023868, 162099064, 162159716, 163565862, 164796410, 164850569, 164868386, 170250164, 170558646, 176278822, 180095770, 184565453, 223258928, 224052761, 225226466
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Target and Pathway | Top | |||
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Target(s) | Calcium-activated potassium channel KCa3.1 (KCNN4) | Target Info | Activator | [2] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2335). | |||
REF 2 | Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95. |
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