Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U8US
|
|||
| Former ID |
DAP001286
|
|||
| Drug Name |
Interferon gamma-1b
|
|||
| Indication | Chronic granulomatous disease [ICD-11: 4A00.0Y; ICD-9: 288.1] | Approved | [1] | |
| Therapeutic Class |
Immunomodulatory Agents
|
|||
| SuperDrug ATC ID |
L03AB03
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interferon gamma receptor (IFNGR2) | Target Info | Binder | [2], [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| HIF-1 signaling pathway | ||||
| Osteoclast differentiation | ||||
| Jak-STAT signaling pathway | ||||
| Natural killer cell mediated cytotoxicity | ||||
| Salmonella infection | ||||
| Leishmaniasis | ||||
| Chagas disease (American trypanosomiasis) | ||||
| Toxoplasmosis | ||||
| Tuberculosis | ||||
| Measles | ||||
| Influenza A | ||||
| Herpes simplex infection | ||||
| Inflammatory bowel disease (IBD) | ||||
| Reactome | Interferon gamma signaling | |||
| Regulation of IFNG signaling | ||||
| WikiPathways | Type II interferon signaling (IFNG) | |||
| Interferon gamma signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):583-9. | |||
| REF 3 | Interferon-gamma 1b for the treatment of idiopathic pulmonary fibrosis. Expert Opin Biol Ther. 2006 Oct;6(10):1051-60. | |||
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