Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U5CE
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| Former ID |
DIB015944
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| Drug Name |
Capsaicin
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| Synonyms |
Capsaicin (transdermal patch formulation, neuropathic pain)
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| Drug Type |
Small molecular drug
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| Indication | Neuropathic pain [ICD-11: 8E43.0] | Approved | [1], [2] | |
| Company |
Samyang Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H27NO3
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| Canonical SMILES |
CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
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| InChI |
1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
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| InChIKey |
YKPUWZUDDOIDPM-SOFGYWHQSA-N
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| CAS Number |
CAS 404-86-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9083, 105773, 853800, 1916595, 7847316, 7978850, 8149724, 8653307, 10321304, 11537699, 12015395, 14923155, 17389996, 17486482, 22391501, 24847432, 24853014, 24853015, 24862158, 24896598, 26612181, 26680132, 26681474, 26744231, 26747263, 26747264, 26752818, 26752819, 26752820, 26758379, 29203915, 32248886, 46487934, 47216576, 47364983, 47515116, 47662075, 47662076, 47736251, 47736252, 47810544, 47885207, 48034884, 48259019, 48413373, 48423080, 48424925, 49688535, 49698675, 49747048
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| ChEBI ID |
CHEBI:3374
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| ADReCS Drug ID | BADD_D00353 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [3] | |||
| Metabolic Reaction | Demethylation | |||
| Experimental Method | High-throughput screening | |||
| Description | Capsaicin can be metabolized by gut microbiota through demethylation. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Agonist | [4], [5] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2486). | |||
| REF 2 | ClinicalTrials.gov (NCT00771511) Cervical Capsaicin for Labor Induction and Pain Relief. U.S. National Institutes of Health. | |||
| REF 3 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 4 | Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71. | |||
| REF 5 | Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival. Clin J Pain. 2008 Feb;24(2):142-54. | |||
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