Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U4XJ
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| Former ID |
DIB008573
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| Drug Name |
Luliconazole
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| Synonyms |
Lulicon; Lulifin; JA-004; JA-005; NND-502; PR-2699
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| Drug Type |
Small molecular drug
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| Indication | Tinea pedis [ICD-11: 1F28.2; ICD-10: B35.3] | Approved | [1] | |
| Dry eye disease [ICD-11: 9E1Z; ICD-9: 370.33] | Phase 2/3 | [2], [3] | ||
| Company |
Medicis
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H9Cl2N3S2
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| Canonical SMILES |
C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl
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| InChI |
1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
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| InChIKey |
YTAOBBFIOAEMLL-REQDGWNSSA-N
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| CAS Number |
CAS 187164-19-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586216, 643960, 7849042, 10037006, 14852125, 14925583, 34668246, 57410170, 76820916, 111612158, 124894110, 124894111, 124894112, 126670212, 135129250, 135916046, 137263766, 141032821, 141032823, 144116152, 144206495, 144206527, 144206804, 152036739, 152258565, 160647400, 160681948, 164827606, 171061169, 175438119, 178103938, 180372162, 185985039, 198977577, 223442283, 223662632, 226677610, 252215718
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| ChEBI ID |
CHEBI:34825
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| ADReCS Drug ID | BADD_D01329 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Cytochrome P450 51 (Candi ERG11) | Target Info | Inhibitor | [4], [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of Valeant pharmaceuticals. | |||
| REF 2 | Clinical pipeline report, company report or official report of Topica Pharmaceuticals. | |||
| REF 3 | ClinicalTrials.gov (NCT01431820) Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis. U.S. National Institutes of Health. | |||
| REF 4 | Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. | |||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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