Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U4WY
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| Former ID |
DIB011426
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| Drug Name |
BILD-1357
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| Synonyms |
BILD 1357; AC1LAKBO; 1-[[2-(2-{2-[(2-Benzyl-4-phenyl-butyryl)-methyl-amino]-3-methyl-butyrylamino}-3,3-dimethyl-butyrylamino)-4-oxo-4-pyrrolidin-1-yl-butyrylamino]-(1-ethyl-2,2-dimethyl-propylcarbamoyl)-methyl]-cyclopentanecarboxylic acid; 1-[(1S)-1-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzyl-4-phenylbutanoyl)-methylamino]-3-methylbutanoyl]amino]-3,3-dimethylbutanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-2-[[(3R)-2,2-dimethylpentan-3-yl]amino]-2-oxoethyl]cyclopentane-1-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Herpes simplex virus infection [ICD-11: 1F00; ICD-10: B00; ICD-9: 54] | Terminated | [1] | |
| Company |
Bio-Mega Research Division
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| Structure |
 |
Download2D MOL
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| Formula |
C51H76N6O8
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| Canonical SMILES |
CCC(C(C)(C)C)NC(=O)C(C1(CCCC1)C(=O)O)NC(=O)C(CC(=O)N2CCCC2)NC(=O)C(C(C)(C)C)NC(=O)C(C(C)C)N(C)C(=O)C(CC3=CC=CC=C3)CC4=CC=CC=C4
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| InChI |
1S/C51H76N6O8/c1-11-38(49(4,5)6)53-46(62)42(51(48(64)65)26-18-19-27-51)55-43(59)37(32-39(58)57-28-20-21-29-57)52-45(61)41(50(7,8)9)54-44(60)40(33(2)3)56(10)47(63)36(30-34-22-14-12-15-23-34)31-35-24-16-13-17-25-35/h12-17,22-25,33,36-38,40-42H,11,18-21,26-32H2,1-10H3,(H,52,61)(H,53,62)(H,54,60)(H,55,59)(H,64,65)/t37-,38+,40-,41+,42+/m0/s1
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| InChIKey |
QRACUPFHILQVKO-ZEIRWQBWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009082) | |||
| REF 2 | Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity. J Med Chem. 1996 Oct 11;39(21):4173-80. | |||
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