Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0U3KP
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| Former ID |
DIB013178
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| Drug Name |
HT-100
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| Synonyms |
Halofunginone
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| Drug Type |
Small molecular drug
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| Indication | Duchenne dystrophy [ICD-11: 8C70; ICD-10: G71.0] | Phase 2 | [1] | |
| Company |
Halo therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H17BrClN3O3
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| Canonical SMILES |
C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
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| InChI |
1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2
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| InChIKey |
LVASCWIMLIKXLA-UHFFFAOYSA-N
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| CAS Number |
CAS 55837-20-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bifunctional aminoacyl-tRNA synthetase (EPRS) | Target Info | Modulator | [2] |
| BioCyc | TRNA charging | |||
| KEGG Pathway | Porphyrin and chlorophyll metabolism | |||
| Aminoacyl-tRNA biosynthesis | ||||
| Metabolic pathways | ||||
| Panther Pathway | Heme biosynthesis | |||
| Pathwhiz Pathway | Arginine and Proline Metabolism | |||
| WikiPathways | Parkinsons Disease Pathway | |||
| tRNA Aminoacylation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02525302) HT-100 Long-term Study in DMD Patients Who Completed HALO-DMD-02. | |||
| REF 2 | Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. | |||
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