Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U3CR
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| Former ID |
DAP000059
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| Drug Name |
Guanadrel Sulfate
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| Synonyms |
Hylorel; Hyloride; Guanadrel sulfate [USAN]; CL 1388R; U 28288D; CL-1388R; Guanadrel sulfate (USP); Hylorel (TN); U 28,288D; U-28288D; Guanadrel sulfate (2:1); Guanidine (1,4-dioxaspiro(4.5)dec-2-ylmethyl)-, sulfate (2:1); (1,4-Dioxaspiro(4.5)dec-2-ylmethyl)guanidine sulfate (2:1); 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1] | |
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
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Download2D MOL |
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| Formula |
C20H40N6O8S
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| Canonical SMILES |
C1CCC2(CC1)OCC(O2)CN=C(N)N.C1CCC2(CC1)OCC(O2)CN=C(N)N.OS(=O)(=O)O
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| InChI |
1S/2C10H19N3O2.H2O4S/c2*11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h2*8H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)
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| InChIKey |
RTEVGQJRTFFMLL-UHFFFAOYSA-N
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| CAS Number |
CAS 22195-34-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:5556
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Guanadrel sulfate (adjusted p-values: 8.72E-03). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor (ADR) | Target Info | Modulator | [3] |
| References | Top | |||
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| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018104. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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