Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TY8S
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| Drug Name |
PMID25522065-Compound-22
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| Drug Type |
Small molecular drug
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| Company |
GLAXOSMITHKLINE LLC CHRISTENSEN, Siegfried, Benjamin, IV QIN, Donghui LU, Shi WEI, Shuai YANG, Nianyong ZHANG, Zhiliu
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H24ClN5O2
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| Canonical SMILES |
CC12CC1(CN(C2)C3=NC=C(C=C3)N4C=CC(=CC4=O)OCC5=NC=C(C=C5)Cl)NC
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| InChI |
1S/C23H24ClN5O2/c1-22-13-23(22,25-2)15-28(14-22)20-6-5-18(11-27-20)29-8-7-19(9-21(29)30)31-12-17-4-3-16(24)10-26-17/h3-11,25H,12-15H2,1-2H3/t22-,23-/m0/s1
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| InChIKey |
KROAARZZGJOXPL-GOTSBHOMSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melanin-concentrating hormone receptor 1 (MCHR1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Melanin-concentrating hormone receptor 1 (MCHR1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. | |||
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