Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TH6M
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| Drug Name |
PMID30259754-Compound-LY2562175
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| Drug Type |
Small molecular drug
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| Company |
ELI LILLY AND COMPANY GENIN, Michael, James AGEJAS-CHICHARRO, Francisco, Javier BUENO MELENDO, Ana, Belen MANNINEN, Peter, Rudolph WARSHAWSKY, Alan, M
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H27Cl2N3O4
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| Canonical SMILES |
CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O
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| InChI |
1S/C28H27Cl2N3O4/c1-32-14-20(28(34)35)19-8-7-17(13-24(19)32)33-11-9-18(10-12-33)36-15-21-26(31-37-27(21)16-5-6-16)25-22(29)3-2-4-23(25)30/h2-4,7-8,13-14,16,18H,5-6,9-12,15H2,1H3,(H,34,35)
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| InChIKey |
RPVDFHPBGBMWID-UHFFFAOYSA-N
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| CAS Number |
CAS 1103500-20-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Farnesoid X-activated receptor (FXR) | Target Info | Agonist | [1] |
| Target's Patent Info | Farnesoid X-activated receptor (FXR) | Target's Patent Info | [1] | |
| KEGG Pathway | Bile secretion | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Recycling of bile acids and salts | |||
| PPARA activates gene expression | ||||
| Endogenous sterols | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Farnesoid X Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. | |||
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