Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TH6L
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| Former ID |
DIB020508
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| Drug Name |
N-desalkylquetiapine
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| Synonyms |
norquetiapine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C17H17N3S
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| Canonical SMILES |
C1CN(CCN1)C2=NC3=CC=CC=C3SC4=CC=CC=C42
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| InChI |
1S/C17H17N3S/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15/h1-8,18H,9-12H2
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| InChIKey |
JLOAJISUHPIQOX-UHFFFAOYSA-N
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| CAS Number |
CAS 5747-48-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16462970, 23525356, 42449147, 49833587, 74458620, 91612199, 117670514, 121278643, 125796408, 126731279, 128292487, 134358675, 135595726, 135707888, 136895425, 137187968, 137354742, 143497646, 151993572, 152236950, 160841887, 162058038, 162120005, 163406888, 163589539, 170558937, 187032767, 187051846, 223578304, 223654964, 223964253, 226399546, 241108396, 251855594, 252236817, 252304551, 252552995
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Norepinephrine transporter (NET) | Target Info | Inhibitor | [2] |
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antipsychotic and antidepressive effects of second generation antipsychotics: two different pharmacological mechanisms. Eur Arch Psychiatry Clin Neurosci. 2005 Jun;255(3):190-201. | |||
| REF 2 | N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant ... Neuropsychopharmacology. 2008 Sep;33(10):2303-12. | |||
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