Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T8SD
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| Former ID |
DIB018555
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| Drug Name |
2-hydroxy-saclofen
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| Synonyms |
2-hydroxy-s-(-)-saclofen; 2-OH-saclofen; 2-hydroxysaclofen
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C9H12ClNO4S
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| Canonical SMILES |
C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl
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| InChI |
1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
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| InChIKey |
WBSMZVIMANOCNX-UHFFFAOYSA-N
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| CAS Number |
CAS 117354-64-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5622930, 7978578, 8151184, 15417339, 17404642, 24278170, 24439891, 24895428, 48334723, 48484010, 49880200, 50104362, 50104363, 53777185, 57320942, 79105089, 85083623, 85230916, 85788093, 90341474, 91703035, 92303657, 104298083, 121361103, 123087479, 124558811, 124749429, 124879238, 126407141, 129558641, 134222192, 135065499, 135374404, 135649709, 142796829, 152053676, 162022513, 162092009, 163124459, 163564033, 204408868, 226675882, 241181592, 242426430, 252332891
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| ChEBI ID |
CHEBI:111179
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Antagonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1068). | |||
| REF 2 | Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. | |||
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