Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T8HZ
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| Drug Name |
Pegvaliase
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| Synonyms |
BMN 165; Pegvaliase [INN]; UNII-N6UAH27EUV; N6UAH27EUV
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| Indication | Phenylketonuria [ICD-11: 5C50.0; ICD-10: E70, E70.1] | Approved | [1] | |
| Company |
BioMarin Pharmaceutical
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| Structure |
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Download2D MOL |
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| Formula |
C15H30N2O5
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| Canonical SMILES |
COCCOCCCCCC(=O)NCCCCC(C(=O)O)N
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| InChI |
1S/C15H30N2O5/c1-21-11-12-22-10-6-2-3-8-14(18)17-9-5-4-7-13(16)15(19)20/h13H,2-12,16H2,1H3,(H,17,18)(H,19,20)/t13-/m0/s1
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| InChIKey |
NPOCDVAOUKODSQ-ZDUSSCGKSA-N
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| CAS Number |
CAS 1585984-95-7
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| PubChem Compound ID | ||||
| ADReCS Drug ID | BADD_D02513 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phenylalanine hydroxylase (PAH) | Target Info | Modulator | [1] |
| BioCyc | Phenylalanine degradation/tyrosine biosynthesis | |||
| KEGG Pathway | Phenylalanine metabolism | |||
| Phenylalanine, tyrosine and tryptophan biosynthesis | ||||
| Metabolic pathways | ||||
| Biosynthesis of amino acids | ||||
| Pathwhiz Pathway | Phenylalanine and Tyrosine Metabolism | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Biogenic Amine Synthesis | ||||
| Metabolism of amino acids and derivatives | ||||
| Abnormal metabolism in phenylketonuria | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Induction, titration, and maintenance dosing regimen in a phase 2 study of pegvaliase for control of blood phenylalanine in adults with phenylketonuria.Mol Genet Metab. 2018 Nov;125(3):217-227. | |||
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