Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T6XX
|
|||
| Former ID |
DAP000724
|
|||
| Drug Name |
Pantoprazole
|
|||
| Synonyms |
Astropan; Pantoprazol; Pantoprazolum; Pantoprozole; Pantor; Pantozol; Protium; Protonix; Somac; Pantoprazole Na; Pantoprazole Sodium; Protonix IV; BY 1023; Astropan (TN); BY-1023; Controloc (TN); Inipomp (TN); Pantecta (TN); Pantoloc (TN); Pantopan (TN); Pantoprazol [INN-Spanish]; Pantoprazolum [INN-Latin]; Pantor (TN); Pantotab (TN); Pantozol (TN); Protium (TN); Protonix (TN); SK&F 96022; SK-96022; SKF-96022; Somac (TN); Ulcepraz (TN); Pantoprazole (USAN/INN); Pantoprazole [USAN:BAN:INN]; SK&F-96022; 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole; 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Gastroesophageal reflux disease [ICD-11: DA22.Z] | Approved | [1], [2] | |
| Therapeutic Class |
Antiulcer Agents
|
|||
| Company |
Wyeth; Altana; Solvay
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C16H15F2N3O4S
|
|||
| Canonical SMILES |
COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
|
|||
| InChI |
1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
|
|||
| InChIKey |
IQPSEEYGBUAQFF-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 102625-70-7
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
13970, 6752164, 7980248, 14902603, 17183107, 17398288, 26526442, 26612946, 26749082, 26749083, 29223767, 46504622, 47959868, 48416375, 49830151, 49882833, 50107519, 50432438, 53788377, 56394975, 57322393, 81040904, 85789648, 91011863, 92124724, 92307944, 92309139, 92711310, 93166161, 103557047, 104098729, 104178843, 104307108, 118318262, 125336751, 126525315, 126630995, 126658184, 126670715, 128206212, 131293114, 134338012, 135028043, 135692424, 136948045, 137088311, 137175473, 141641906, 141641915, 142318542
|
|||
| ChEBI ID |
CHEBI:7915
|
|||
| ADReCS Drug ID | BADD_D01668 ; BADD_D01669 | |||
| SuperDrug ATC ID |
A02BC02
|
|||
| SuperDrug CAS ID |
cas=102625707
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Alistipes indistinctus DSM22520
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -1.689; p = 0.001). | |||
|
Studied Microbe: Bacteroides caccae ATCC 43185
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -2.773; p = 0.008). | |||
|
Studied Microbe: Bacteroides cellulosilyticus DSM 14838
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -10.503; p = 0.003). | |||
|
Studied Microbe: Bacteroides coprophilus DSM 18228
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.73; p = 0.007). | |||
|
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -10.711; p = 0.003). | |||
|
Studied Microbe: Bacteroides eggerthii DSM20697
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -1.959; p = 0.003). | |||
|
Studied Microbe: Bacteroides finegoldii DSM17565
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -3.707; p = 0.002). | |||
|
Studied Microbe: Bacteroides fragilis ATCC43859
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -2.158; p = 0.0). | |||
|
Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -2.267; p = 0.003). | |||
|
Studied Microbe: Bacteroides fragilis HMW 615
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -1.621; p = 0.003). | |||
|
Studied Microbe: Bacteroides fragilis NCTC 9343
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -2.307; p = 0.004). | |||
|
Studied Microbe: Bacteroides fragilis str. 3397 T10
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -1.695; p = 0.001). | |||
|
Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -2.069; p = 0.001). | |||
|
Studied Microbe: Bacteroides fragilis str. DS-208
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -1.966; p = 0.0). | |||
|
Studied Microbe: Bacteroides intestinalis DSM 17393
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -3.116; p = 0.0). | |||
|
Studied Microbe: Bacteroides ovatus ATCC 8483
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -1.952; p = 0.001). | |||
|
Studied Microbe: Bacteroides stercoris ATCC 43183
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -1.417; p = 0.001). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 3731
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -1.835; p = 0.0). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 7330
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.624; p = 0.004). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.729; p = 0.005). | |||
|
Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -2.232; p = 0.0). | |||
|
Studied Microbe: Bacteroides vulgatus ATCC 8482
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -10.705; p = 0.003). | |||
|
Studied Microbe: Bacteroides WH2
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides WH2 (log2FC = -1.928; p = 0.006). | |||
|
Studied Microbe: Bacteroides xylanisolvens DSM18836
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -2.779; p = 0.005). | |||
|
Studied Microbe: Odoribacter splanchnicus
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Odoribacter splanchnicus (log2FC = -1.449; p = 0.002). | |||
|
Studied Microbe: Parabacteroides distasonis ATCC 8503
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -2.99; p = 0.012). | |||
|
Studied Microbe: Parabacteroides johnsonii DSM 18315
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -3.462; p = 0.001). | |||
|
Studied Microbe: Parabacteroides merdae ATCC 43184
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -1.709; p = 0.0). | |||
|
Studied Microbe: Pretovella copri DSM 18205
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Pretovella copri DSM 18205 (log2FC = -4.312; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
|
Studied Microbe: Bifidobacterium adolescentis ATCC 15703
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -1.373; p = 0.004). | |||
|
Studied Microbe: Bifidobacterium breve DSM 20213
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -4.484; p = 0.006). | |||
|
Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -1.468; p = 0.0). | |||
|
Studied Microbe: Bifidobacterium ruminantium
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bifidobacterium ruminantium (log2FC = -1.706; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
|
Studied Microbe: Collinsella aerofaciens ATCC25986
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -6.12; p = 0.016). | |||
|
Studied Microbe: Collinsella intestinalis DSM 13280
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -1.406; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
|
Studied Microbe: Eggerthella lenta ATCC 25559
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -2.188; p = 0.0). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Edwardsiella tarda ATCC 23685
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -7.542; p = 0.003). | |||
|
Studied Microbe: Enterobacter cancerogenus ATCC35316
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -7.617; p = 0.003). | |||
|
Studied Microbe: Escherichia coli BW25113
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Escherichia coli BW25113 (log2FC = -1.945; p = 0.0). | |||
|
Studied Microbe: Proteus penneri ATCC 35198
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Proteus penneri ATCC 35198 (log2FC = -5.443; p = 0.003). | |||
|
Studied Microbe: Providencia alcalifaciens DSM 30120
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -2.112; p = 0.04). | |||
|
Studied Microbe: Providencia rettgeri DSM 1131
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -1.788; p = 0.002). | |||
|
Studied Microbe: Providencia stuartii ATCC 25827
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -8.09; p = 0.003). | |||
|
Studied Microbe: Salmonella typhimurium LT2
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Salmonella typhimurium LT2 (log2FC = -1.086; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Clostridium ramosum DSM 1402
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -2.55; p = 0.002). | |||
|
Studied Microbe: Clostridium spiroforme DSM1552
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -9.853; p = 0.003). | |||
|
Studied Microbe: Eubacterium biforme DSM 3989
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -1.387; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Anaerostipes sp.
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Anaerostipes sp. (log2FC = -3.543; p = 0.0). | |||
|
Studied Microbe: Anaerotruncus colihominis DSM 17241
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -3.17; p = 0.0). | |||
|
Studied Microbe: Bacteroides pectinophilus ATCC 43243
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -2.76; p = 0.03). | |||
|
Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Blautia hansenii DSM20583 (log2FC = -2.119; p = 0.002). | |||
|
Studied Microbe: Blautia luti DSM 14534
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Blautia luti DSM 14534 (log2FC = -1.642; p = 0.002). | |||
|
Studied Microbe: Bryantia formatexigens DSM 14469
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -1.043; p = 0.008). | |||
|
Studied Microbe: Clostridium asparagiforme DSM 15981
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -1.948; p = 0.017). | |||
|
Studied Microbe: Clostridium difficile 120
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium difficile 120 (log2FC = -1.87; p = 0.007). | |||
|
Studied Microbe: Clostridium hathewayi DSM 13479
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -5.579; p = 0.003). | |||
|
Studied Microbe: Clostridium scindens ATCC 35704
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -3.42; p = 0.002). | |||
|
Studied Microbe: Clostridium sp.
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium sp. (log2FC = -2.079; p = 0.004). | |||
|
Studied Microbe: Clostridium sporogenes ATCC 15579
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -1.252; p = 0.01). | |||
|
Studied Microbe: Clostridium symbiosum ATCC 14940
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -4.399; p = 0.001). | |||
|
Studied Microbe: Coprococcus comes ATCC 27758
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -1.892; p = 0.021). | |||
|
Studied Microbe: Dorea formicigenerans ATCC 27755
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -9.027; p = 0.003). | |||
|
Studied Microbe: Enterocloster bolteae ATCC BAA-613
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -3.643; p = 0.001). | |||
|
Studied Microbe: Eubacterium hallii DSM3353
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Eubacterium hallii DSM3353 (log2FC = -0.732; p = 0.006). | |||
|
Studied Microbe: Eubacterium rectale ATCC 33656
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -1.421; p = 0.005). | |||
|
Studied Microbe: Eubacterium ventriosum ATCC 27560
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -6.097; p = 0.003). | |||
|
Studied Microbe: Roseburia intestinalis L1-82
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Roseburia intestinalis L1-82 (log2FC = -1.147; p = 0.002). | |||
|
Studied Microbe: Ruminococcus gnavus ATCC 29149
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -1.484; p = 0.001). | |||
|
Studied Microbe: Ruminococcus lactaris ATCC 29176
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -5.181; p = 0.003). | |||
|
Studied Microbe: Ruminococcus torques ATCC 27756
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -0.958; p = 0.01). | |||
|
Studied Microbe: Subdoligranulum variabile DSM 15176
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -1.337; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus faecalis V583
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Enterococcus faecalis V583 (log2FC = -2.065; p = 0.003). | |||
|
Studied Microbe: Lactobacillus reuteri CF48-3A
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.879; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
|
Studied Microbe: Anaerococcus hydrogenalis DSM 7454
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -6.747; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
|
Studied Microbe: Akkermansia muciniphila ATCC BAA-835
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -0.859; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
|
Studied Microbe: Victivallis vadensis ATCC BAA-548
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -0.887; p = 0.024). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Metabolic Reaction | Sulfur reduction | |||
| Experimental Method | High-throughput screening | |||
| Description | Pantoprazole can be metabolized by gut microbiota through sulfur reduction. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gastric H(+)/K(+) ATPase (Proton pump) | Target Info | Modulator | [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7260). | |||
| REF 2 | An overview of proton pump inhibitors. Gastroenterol Nurs. 2003 Sep-Oct;26(5):182-90. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.