Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T4NV
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| Former ID |
DIB009068
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| Drug Name |
CDX-1135
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| Synonyms |
SCR1; BRL-55730; Soluble complement receptor type 1, AVANT; Soluble complement receptor type 1, Celldex; YM-203; TP-10, AVANT Immunotherapeutics; TP-10, Celldex
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| Indication | Macular degeneration [ICD-11: 9B78.3; ICD-10: H35.3; ICD-9: 362.5] | Phase 1 | [1] | |
| Company |
Celldex therapeutics
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Complement receptor type 1 (CR1) | Target Info | Modulator | [2] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Hematopoietic cell lineage | ||||
| Legionellosis | ||||
| Leishmaniasis | ||||
| Malaria | ||||
| Tuberculosis | ||||
| Reactome | Regulation of Complement cascade | |||
| WikiPathways | Complement and Coagulation Cascades | |||
| Human Complement System | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Complement cascade | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01791686) Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease. U.S. National Institutes of Health. | |||
| REF 2 | Complement activation is critical for placental ischemia-induced hypertension in the rat. Mol Immunol. 2013 Nov;56(1-2):91-7. | |||
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