Drug Information
Drug General Information | Top | |||
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Drug ID |
D0T1ZM
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Former ID |
DNC010235
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Drug Name |
NSC-745883
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Synonyms |
2-(4-Cyanophenyl)-1H-anthra[1,2-d]imidazole-6,11-dione; 1190059-23-4; NSC-745883; SCHEMBL2399352; CHEMBL603647; ZINC45390864; 2-(4-Cyanophenyl)-1H-anthra-[1,2-d]imidazole-6,11-dione, 97%, AldrichCPR
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C22H11N3O2
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Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=C(C=C3)NC(=N4)C5=CC=C(C=C5)C#N
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InChI |
1S/C22H11N3O2/c23-11-12-5-7-13(8-6-12)22-24-17-10-9-16-18(19(17)25-22)21(27)15-4-2-1-3-14(15)20(16)26/h1-10H,(H,24,25)
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InChIKey |
KHYKISCIUUOMQS-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
KEGG Pathway | HTLV-I infection | |||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
Regulation of Telomerase | ||||
IL2 signaling events mediated by PI3K | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
WikiPathways | TGF beta Signaling Pathway | |||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in epithelium - TarBase | ||||
Telomere Maintenance |
References | Top | |||
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REF 1 | Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. |
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