Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SD1L
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| Drug Name |
Mercaptopurine
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| Synonyms |
6-mercaptopurine; Ismipur; Leukerin; Leupurin; Mercaleukim; Mercaleukin; Mercaptopurin; Mercaptopurina; Mercaptopurinum; Mercapurin; Merkaptopuryna; Mern; Purimethol; Purinethiol; Purinethol; Thiopurine; Leupu rin; Mercaptopurin [German]; Mercaptopurina Wellcome; Mercaptopurine anhydrous; Merkaptopuryna [Polish]; Puri Nethol; BW 57 323H; Glaxo Wellcome Brand of 6 Mercaptopurine; GlaxoSmithKline Brand of 6 Mercaptopurine; M0063; NCIMech_000025; PM6; Wellcome Brand of 6 Mercaptopurine; Glaxo Wellcome Brand of 6-Mercaptopurine; GlaxoSmithKline Brand of 6-Mercaptopurine; Mercaptopurina [INN-Spanish]; Mercaptopurine (INN); Mercaptopurine (VAN); Mercaptopurine (anhydrous); Mercaptopurinum [INN-Latin]; Puri-Nethol; Purineantimetabolite: inhibits nucleic acid replication; Purinethol (TN); U-4748; Wellcome Brand of 6-Mercaptopurine; AG-670/31547064; Purine-6-thiol; Leukerin, 99%-Carc; Purine-6(1H)-thione; Purinethol, 6-mercaptopurine, 6-MP, Mercaptopurine; 6 MP; 6 Mercaptopurine Monohydrate; 6 Thiohypoxanthine; 6 Thiopurine; 6-MERCAPTOPURINE MONOHYDRATE; 6-MP; 6-Mercaptopurin; 6-Merkaptopurin; 6-Merkaptopurin [Czech]; 6-Purinethiol; 6-Thiohypoxanthine; 6-Thiopurine; 6-Thioxopurine; Mercaptopurine (Purine analog)
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| Drug Type |
Small molecular drug
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| Indication | Acute lymphocytic leukaemia [ICD-11: 2B33.3; ICD-10: C91, C91.9] | Approved | [1] | |
| Middle East Respiratory Syndrome (MERS) [ICD-11: 1D64] | Preclinical | [2] | ||
| Severe acute respiratory syndrome (SARS) [ICD-11: 1D65] | Preclinical | [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Company |
Novopharm
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| Structure |
 |
Download2D MOL |
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| Formula |
C5H4N4S
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| Canonical SMILES |
C1=NC2=C(N1)C(=S)N=CN2
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| InChI |
1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
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| InChIKey |
GLVAUDGFNGKCSF-UHFFFAOYSA-N
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| CAS Number |
CAS 50-44-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4889, 5422, 538245, 602747, 3205553, 4912489, 5334583, 5370645, 6477910, 7366114, 7979906, 8136889, 8148223, 8149413, 9276666, 11335668, 11360907, 11363815, 11364775, 11366377, 11367337, 11368939, 11369899, 11371581, 11372939, 11374631, 11375499, 11377101, 11378064, 11446005, 11446674, 11461879, 11483955, 11487876, 11490307, 11492672, 11494735, 14772317, 15321640, 15970891, 16997018, 24882910, 25622685, 26611807, 26679290, 26748122, 26748123, 26748124, 31299583, 31665082
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| ChEBI ID |
CHEBI:2208
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | MERS-CoV papain-like proteinase (PL-PRO) | Target Info | Inhibitor | [2] |
| SARS-CoV papain-like proteinase (PL-PRO) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16. | |||
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