Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S9XV
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Former ID |
DIB003473
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Drug Name |
A-134974
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Synonyms |
a-134974; GTPL5130; CHEMBL1591918; ZINC3827162; SMP2_000021; NCGC00186045-01; A134974; A 134974
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Drug Type |
Small molecular drug
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Indication | Epilepsy [ICD-11: 8A60-8A68] | Terminated | [1], [2] | |
Company |
Abbott Laboratories
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Structure |
Download2D MOL |
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Formula |
C11H14IN5O2
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Canonical SMILES |
C1C(C(C(C1N2C=C(C3=C(N=CN=C32)N)I)O)O)N
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InChI |
1S/C11H14IN5O2/c12-4-2-17(6-1-5(13)8(18)9(6)19)11-7(4)10(14)15-3-16-11/h2-3,5-6,8-9,18-19H,1,13H2,(H2,14,15,16)/t5-,6+,8+,9-/m0/s1
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InChIKey |
NSXJHIFQIZKLGF-LWIVVEGESA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Adenosine kinase (ADK) | Target Info | Inhibitor | [3] |
BioCyc | Superpathway of purine nucleotide salvage | |||
Adenine and adenosine salvage II | ||||
KEGG Pathway | Purine metabolism | |||
Metabolic pathways | ||||
Reactome | Purine salvage | |||
WikiPathways | Metabolism of nucleotides |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5130). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009094) | |||
REF 3 | Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action. J Pharmacol Exp Ther. 2001Feb;296(2):501-9. |
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