Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S5YH
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| Former ID |
DIB020888
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| Drug Name |
saclofen
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| Synonyms |
saclofen; 125464-42-8; 3-amino-2-(4-chlorophenyl)propane-1-sulfonic acid; beta-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid; CHEMBL312403; (RS)-3-amino-2-(4-chlorophenyl)propylsulfonic acid; AK-86940; Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-; 3-AMINO-2-(4-CHLOROPHENYL)-PROPANE SULFONIC ACID; Saclofen, solid; Saclofen HCl; Biomol-NT_000242; SCHEMBL339757; BPBio1_000705; GTPL1078; AC1L3U31; CHEBI:91596; CTK8B4660; MolPort-003-824-767; HMS3266E05; BCP16740; BN0452; ANW-45829; MFCD00216817; BDBM50286225
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C9H12ClNO3S
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| Canonical SMILES |
C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl
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| InChI |
1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
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| InChIKey |
JYLNVJYYQQXNEK-UHFFFAOYSA-N
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| CAS Number |
CAS 125464-42-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3190659, 6317718, 7978530, 10239965, 15122183, 26751661, 29302596, 47513075, 47734113, 50070504, 50071145, 52092379, 57339985, 85083624, 85209931, 85788319, 91590738, 103280636, 104127796, 104415162, 126434985, 128345664, 135076057, 135650976, 137010114, 142796831, 160813327, 162022515, 162093587, 162204513, 163089574, 163374438, 163837910, 164844936, 171578639, 184592327, 204402940, 226675178, 241181593, 249825384, 250208358, 252059222, 252213990, 252316132, 252430556
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| ChEBI ID |
CHEBI:91596
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1078). | |||
| REF 2 | Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. | |||
| REF 3 | Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochem Pharmacol. 2003 Apr 1;65(7):1103-13. | |||
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