Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S5QB
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Former ID |
DNC003608
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Drug Name |
KYS-05040
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Synonyms |
KYS-05040; CHEMBL115159; SCHEMBL14417350; BDBM50148177; N-(4-Amino-benzyl)-2-(3-phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C28H31N5O
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Canonical SMILES |
C1CCN(CC1)C2=NC3=CC=CC=C3C(N2C4=CC=CC=C4)CC(=O)NCC5=CC=C(C=C5)N
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InChI |
1S/C28H31N5O/c29-22-15-13-21(14-16-22)20-30-27(34)19-26-24-11-5-6-12-25(24)31-28(32-17-7-2-8-18-32)33(26)23-9-3-1-4-10-23/h1,3-6,9-16,26H,2,7-8,17-20,29H2,(H,30,34)
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InChIKey |
NEMYASVJMUEWED-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) | Target Info | Inhibitor | [1] |
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) | Target Info | Inhibitor | [1] | |
KEGG Pathway | MAPK signaling pathway | |||
Calcium signaling pathway | ||||
Circadian entrainment | ||||
Type II diabetes mellitus | ||||
Panther Pathway | Endogenous cannabinoid signaling | |||
GABA-B receptor II signaling | ||||
Nicotine pharmacodynamics pathway | ||||
Pathwhiz Pathway | Muscle/Heart Contraction | |||
Pathway Interaction Database | Regulation of nuclear beta catenin signaling and target gene transcription | |||
Reactome | NCAM1 interactions | |||
WikiPathways | NCAM signaling for neurite out-growth | |||
Nicotine Activity on Chromaffin Cells | ||||
Corticotropin-releasing hormone |
References | Top | |||
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REF 1 | 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84. |
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