Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S4JY
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Former ID |
DIB013453
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Drug Name |
Ro-24-4736
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Synonyms |
Ro-24-4736; Ro 24-4736; UNII-I2MJ13SOFO; I2MJ13SOFO; 125030-71-9; CHEMBL277650; 5-(3-(4-(2-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-2-yl)-2-propynyl)phenanthridin-6(5H)-one; AC1L1TWB; AC1Q3P7I; SCHEMBL7528667; DTXSID80154550; ro24-4736; ZINC1550948; BDBM50011638; CS-6683; HY-19097; 5-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-5H-phenanthridin-6-one; 6(5H)-Phenanthridinone, 5-(3-(4-(2-chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triaz
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Drug Type |
Small molecular drug
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Indication | Sepsis [ICD-11: 1G40-1G41; ICD-10: R57.2; ICD-9: 785.52] | Discontinued in Phase 2 | [1] | |
Company |
Roche Holding AG
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Structure |
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Download2D MOL |
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Formula |
C31H20ClN5OS
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Canonical SMILES |
CC1=NN=C2N1C3=C(C=C(S3)C#CCN4C5=CC=CC=C5C6=CC=CC=C6C4=O)C(=NC2)C7=CC=CC=C7Cl
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InChI |
1S/C31H20ClN5OS/c1-19-34-35-28-18-33-29(24-13-4-6-14-26(24)32)25-17-20(39-31(25)37(19)28)9-8-16-36-27-15-7-5-11-22(27)21-10-2-3-12-23(21)30(36)38/h2-7,10-15,17H,16,18H2,1H3
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InChIKey |
MPMZSZMDCRPSRF-UHFFFAOYSA-N
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CAS Number |
CAS 125030-71-9
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Platelet-activating factor receptor (PTAFR) | Target Info | Antagonist | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Staphylococcus aureus infection | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
Leptin Signaling Pathway | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (q) signalling events | ||||
Interferon gamma signaling | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Small Ligand GPCRs | ||||
Interferon gamma signaling | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001180) | |||
REF 2 | Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85. |
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