Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S4BR
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Former ID |
DAP000763
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Drug Name |
Methimazole
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Synonyms |
methimazole; 60-56-0; thiamazole; Tapazole; 2-Mercapto-1-methylimidazole; Mercazolyl; 1-Methylimidazole-2-thiol; Thymidazole; Mercazole; Methimazol; Thymidazol; Thiamazol; Metazolo; Thycapzol; Metothyrine; Metothyrin; Merkazolil; Mercaptazole; Strumazol; Favistan; Basolan; Thycapsol; Metotirin; Danantizol; Thacapzol; Merkastan; Frentirox; Metizol; Tiamazol; Mercasolyl; 1-Methyl-1H-imidazole-2-thiol; Methylmercaptoimidazole; 1-Methyl-2-mercaptoimidazole; Methiamazole; Usaf el-30; Methimazolum; Mercazolylum; Tapuzole; Metimazol; Thimazole; Basolan; MMZ; Mercazol; Methamazole; Methizol; Methymazol; Metisol; Strumazole; Thiamazole; Thiamazolum; Thimazol; Thyrozol; Tiamazolo; Tirodril; EliLilly Brand of Methimazole; Estedi Brand of Methimazole; Henning Berlin Brand of Methimazole; Hexal Brand of Methimazole; Jones Brand of Methimazole; Merck Brand of Methimazole; Nourypharma Brand of Methimazole; Philopharm Brand of Methimazole; Sanofi Synthelabo Brand of Methimazole; Temmler Brand of Methimazole; Thiamazol Henning; Thiamazol Hexal; Tiamazolo [DCIT]; M0868; Henning, Thiamazol; Hexal, Thiamazol; Methimazole (USP); Methimazole [USAN:BAN]; Tapazole (TN); Thiamazol [INN-French]; Thiamazolum [INN-Latin]; Tiamazol [INN-Spanish]; Mestinon, Regonol, Pyridostigmine Bromide;Thiamazole (JP15/INN); N-Methyl-2-mercaptoimidazole; 1 Methyl 2 mercaptoimidazole; 1,3-Dihydro-1-Methyl-2H-Imidazol-2-Thione; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione; 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE; 1-Methyl-1,3-dihydroimidazole-2-thione; 1-Methyl-2-Imidazolethione; 1-Methyl-2-imidazolethiol; 1-Methyl-imidazole-2-thiol; 1-Methylimidazole-2(3H)-thione; 1-Metylo 2 merkaptoimidazolem; 1-Metylo 2 merkaptoimidazolem [Polish]; 2-Mercaptomethylimidazole; 3-methyl-1H-imidazole-2-thione
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Drug Type |
Small molecular drug
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Indication | Hyperthyroidism [ICD-11: 5A02; ICD-10: E05; ICD-9: 242] | Approved | [1], [2] | |
Therapeutic Class |
Antithyroid Agents
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Structure |
Download2D MOL |
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Formula |
C4H6N2S
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Canonical SMILES |
CN1C=CNC1=S
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InChI |
1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
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InChIKey |
PMRYVIKBURPHAH-UHFFFAOYSA-N
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CAS Number |
CAS 60-56-0
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PubChem Compound ID | ||||
PubChem Substance ID |
9399, 94517, 1668819, 3133765, 3347551, 3718115, 5065194, 5645940, 7847467, 7979929, 8139973, 8149418, 8830281, 10321919, 10529311, 11112158, 11335363, 11360602, 11363889, 11366451, 11369013, 11371589, 11373654, 11377175, 11461574, 11466814, 11467934, 11485002, 11486567, 11489089, 11490311, 11491863, 11494809, 11534268, 15194357, 15297082, 24858194, 24870159, 24882870, 24897266, 25623340, 26611812, 26679219, 26748131, 26748132, 29832410, 38350462, 46506536, 47365373, 47440128
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ChEBI ID |
CHEBI:50673
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ADReCS Drug ID | BADD_D01414 | |||
SuperDrug ATC ID |
H03BB02
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SuperDrug CAS ID |
cas=000060560
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Target and Pathway | Top | |||
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Target(s) | Thyroid peroxidase (TPO) | Target Info | Inhibitor | [3] |
BioCyc | Thyroid hormone biosynthesis | |||
KEGG Pathway | Tyrosine metabolism | |||
Metabolic pathways | ||||
Thyroid hormone synthesis | ||||
Autoimmune thyroid disease | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Pathwhiz Pathway | Thyroid hormone synthesis | |||
Reactome | Thyroxine biosynthesis | |||
WikiPathways | Hematopoietic Stem Cell Differentiation | |||
Differentiation Pathway | ||||
Metabolism of amino acids and derivatives | ||||
Thyroxine (Thyroid Hormone) Production |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6649). | |||
REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040350. | |||
REF 3 | Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study. Eur J Endocrinol. 1994 Nov;131(5):467-73. |
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