Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S3NU
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| Former ID |
DIB012949
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| Drug Name |
Delamanid
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| Synonyms |
OPC-67683; Nitro-dihydroimidazo-oxazole derivatives (tuberculosis), Otsuka; 2-nitroimidazole derivatives (tuberculosis), Otsuka
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| Drug Type |
Small molecular drug
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| Indication | Multi-drug resistant tuberculosis [ICD-11: MG52.00] | Approved | [1] | |
| Mycobacterium infection [ICD-11: 1B10-1B21] | Phase 3 | [2] | ||
| Company |
Otsuka pharmaceutical
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H25F3N4O6
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| Canonical SMILES |
CC1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F
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| InChI |
1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
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| InChIKey |
XDAOLTSRNUSPPH-XMMPIXPASA-N
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| CAS Number |
CAS 681492-22-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:134742
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| ADReCS Drug ID | BADD_D00602 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Cell membrane (Bact CM) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Compassionate use of delamanid in adults and children for drug-resistant tuberculosis: 5-year update. Eur Respir J. 2021 May 20;57(5):2002483. | |||
| REF 2 | ClinicalTrials.gov (NCT01424670) Safety and Efficacy Trial of Delamanid for 6 Months in Patients With Multidrug Resistant Tuberculosis. U.S. National Institutes of Health. | |||
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