Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S1ZB
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| Former ID |
DNC003472
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| Drug Name |
Fotemustine
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| Synonyms |
Fotemustine; 92118-27-9; Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate; Muphoran; Mustophorane; Servier-10036; Fotemustinum [Latin]; Fotemustina [Spanish]; S 10036; C9H19ClN3O5P; CCRIS 6337; S-10036; Fotemustinum; Diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate; (+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate; Mustoforan; 1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea; Fotemustine [BAN:INN]
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H19ClN3O5P
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| Canonical SMILES |
CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
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| InChI |
1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)
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| InChIKey |
YAKWPXVTIGTRJH-UHFFFAOYSA-N
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| CAS Number |
CAS 92118-27-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10233616, 12014105, 14850293, 44434403, 50007504, 51091593, 53789878, 57337850, 77359172, 103687077, 104372956, 123121563, 125667388, 129767251, 131330333, 135061489, 136342498, 136376433, 137248567, 140705803, 143108262, 152059694, 160821170, 162179195, 162248706, 163091479, 164814774, 172093741, 172901031, 174007311, 174476560, 179151435, 184545980, 185979163, 203355731, 204376333, 210279835, 210282158, 223381727, 223704583, 223704584, 226399955, 241176244, 242065940, 249740161, 249850102, 250180288, 250228316, 252034746, 252312364
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| ChEBI ID |
CHEBI:131852
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| ADReCS Drug ID | BADD_D00973 | |||
| SuperDrug ATC ID |
L01AD05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cytoplasmic thioredoxin reductase (TXNRD1) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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