Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S0EQ
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Former ID |
DIB013717
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Drug Name |
AZD-0865
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Synonyms |
AR-H044277
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Drug Type |
Small molecular drug
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Indication | Gastrointestinal disease [ICD-11: DE2Z] | Phase 2 | [1] | |
Company |
AstraZeneca plc
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Structure |
Download2D MOL |
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Formula |
C21H26N4O2
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Canonical SMILES |
CC1=C(C(=CC=C1)C)CNC2=CC(=CN3C2=NC(=C3C)C)C(=O)NCCO
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InChI |
1S/C21H26N4O2/c1-13-6-5-7-14(2)18(13)11-23-19-10-17(21(27)22-8-9-26)12-25-16(4)15(3)24-20(19)25/h5-7,10,12,23,26H,8-9,11H2,1-4H3,(H,22,27)
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InChIKey |
GHVIMBCFLRTFHI-UHFFFAOYSA-N
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CAS Number |
CAS 248919-64-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Gastric H(+)/K(+) ATPase (Proton pump) | Target Info | Modulator | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00206284) A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis.. U.S. National Institutes of Health. | |||
REF 2 | Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73(2):198-205. |
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