Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0RV9D
|
|||
| Drug Name |
PMID25726713-Compound-20
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
IMPACT THERAPEUTICS, INC. CAI, Suixiong TIAN, Ye Edward WANG, Xiaozhu XIE, Kai LI, Sicun YU, Zenghui GU, Chengyun LIU, Lijun
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C26H24ClN5O3
|
|||
| Canonical SMILES |
CC(C)OC1=CC2=C(C=C1)N=C(N2)C3=C(C=CC(=C3)NC4=NC=NC5=C4C=C(C=C5OC)OC)Cl
|
|||
| InChI |
1S/C26H24ClN5O3/c1-14(2)35-16-6-8-21-22(11-16)32-26(31-21)18-9-15(5-7-20(18)27)30-25-19-10-17(33-3)12-23(34-4)24(19)28-13-29-25/h5-14H,1-4H3,(H,31,32)(H,28,29,30)
|
|||
| InChIKey |
UTABPCPBPRTBQJ-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Smoothened homolog (SMO) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Smoothened homolog (SMO) | Target's Patent Info | [1] | |
| KEGG Pathway | Hedgehog signaling pathway | |||
| Pathways in cancer | ||||
| Proteoglycans in cancer | ||||
| Basal cell carcinoma | ||||
| Panther Pathway | Hedgehog signaling pathway | |||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | |||
| Hedgehog signaling events mediated by Gli proteins | ||||
| Reactome | Class B/2 (Secretin family receptors) | |||
| Hedgehog 'off' state | ||||
| Activation of SMO | ||||
| WikiPathways | Hedgehog Signaling Pathway | |||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | ||||
| Hair Follicle Development: Induction (Part 1 of 3) | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| GPCR ligand binding | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.