Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0RU0O
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| Former ID |
DNCL002254
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| Drug Name |
IPI-145
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| Synonyms |
Duvelisib; 1201438-56-3; INK-1197; UNII-610V23S0JI;
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| Drug Type |
Small molecular drug
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| Indication | Follicular lymphoma [ICD-11: 2A80; ICD-9: 202] | Approved | [1] | |
| Small lymphocytic lymphoma [ICD-11: 2A82.0; ICD-10: C83.0, C91.1] | Approved | [1] | ||
| Arthritis [ICD-11: FA20] | Phase 3 | [2], [3] | ||
| Company |
Verastem
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H17ClN6O
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| Canonical SMILES |
CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
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| InChI |
1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
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| InChIKey |
SJVQHLPISAIATJ-ZDUSSCGKSA-N
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| CAS Number |
CAS 1201438-56-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
111324357, 138078918, 152258752, 160647597, 164117634, 164178288, 172096445, 174510187, 176251577, 184816717, 189253961, 198973906, 208265525, 215785773, 223366126, 223382647, 223637384, 224572798, 226518141, 249301356, 249814537, 249855670, 251963115, 252068909, 252444159, 252451775, 252543445, 252552918
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| ChEBI ID |
CHEBI:131169
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| ADReCS Drug ID | BADD_D02495 | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7795). | |||
| REF 3 | PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74. | |||
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