Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0RE6T
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| Former ID |
DIB014457
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| Drug Name |
Telotristat ethyl
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| Synonyms |
Telotristat; Telotristat etiprate; LP-778902; LX-1032; LX-1606; Serotonin modulator (oral, GI disorder/hypertension/carcinoid syndrome), Lexicon; Tryptophan hydroxylase inhibitor (oral, GI disorder/hypertension/carcinoid syndrome), Lexicon
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| Drug Type |
Small molecular drug
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| Indication | Carcinoid syndrome [ICD-11: 5B10; ICD-10: E34.0] | Approved | [1] | |
| Carcinoid syndrome diarrhea [ICD-11: DA90.0; ICD-10: K52.9] | Approved | [2], [3] | ||
| Company |
Lexicon Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C27H26ClF3N6O3
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| Canonical SMILES |
CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N
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| InChI |
1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1
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| InChIKey |
MDSQOJYHHZBZKA-GBXCKJPGSA-N
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| CAS Number |
CAS 1033805-22-9
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| PubChem Compound ID | ||||
| ADReCS Drug ID | BADD_D02503 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptophan hydroxylase (TPH) | Target Info | Modulator | [4] |
| References | Top | |||
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| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018 | |||
| REF 3 | 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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