Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0RD0R
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| Former ID |
DIB020819
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| Drug Name |
Ro 40-6055
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| Synonyms |
AM580; CD-336; Ro406055
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H25NO3
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| Canonical SMILES |
CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C
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| InChI |
1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
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| InChIKey |
SZWKGOZKRMMLAJ-UHFFFAOYSA-N
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| CAS Number |
CAS 102121-60-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
226594, 485051, 7427144, 8151443, 11113688, 11120017, 11120505, 11120993, 11121592, 11122072, 11147100, 11362661, 11365223, 11367785, 11370593, 11370594, 11373386, 11375947, 11409107, 14925445, 17396610, 24891374, 26751874, 26751875, 26751876, 26751877, 29221305, 47515075, 48110196, 48184733, 49888252, 50104563, 53789577, 56312171, 56312842, 57321158, 76148420, 85788728, 91703080, 92309943, 93578139, 99300857, 99302375, 103136884, 103264927, 103949291, 104046497, 104299679, 117545762, 124886942
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| ChEBI ID |
CHEBI:64210
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor alpha (RARA) | Target Info | Agonist | [2] |
| KEGG Pathway | Pathways in cancer | |||
| Transcriptional misregulation in cancer | ||||
| Acute myeloid leukemia | ||||
| Pathway Interaction Database | Retinoic acid receptors-mediated signaling | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Adipogenesis | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2647). | |||
| REF 2 | Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. Mol Pharmacol. 1991 Oct;40(4):556-62. | |||
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