Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R7YI
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| Drug Name |
PMID30107136-Compound-Example13
|
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| Drug Type |
Small molecule immunotherapy
|
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
POLARIS PHARMACEUTICALS, INC
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C42H46Br2N2O6
|
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| Canonical SMILES |
CC1=C(C=CC=C1C2=CC=CC(=C2C)COC3=C(C=C(C=C3)CN4CCCCC4C(=O)O)Br)COC5=C(C=C(C=C5)CN6CCCCC6C(=O)O)Br
|
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| InChI |
1S/C42H46Br2N2O6/c1-27-31(25-51-39-17-15-29(21-35(39)43)23-45-19-5-3-13-37(45)41(47)48)9-7-11-33(27)34-12-8-10-32(28(34)2)26-52-40-18-16-30(22-36(40)44)24-46-20-6-4-14-38(46)42(49)50/h7-12,15-18,21-22,37-38H,3-6,13-14,19-20,23-26H2,1-2H3,(H,47,48)(H,49,50)/t37-,38-/m0/s1
|
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| InChIKey |
SDCCYXRWWJGRKC-UWXQCODUSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target Info | Inhibitor | [1] |
| Target's Patent Info | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target's Patent Info | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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