Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R7LQ
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| Former ID |
DNC008659
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| Drug Name |
Dideazaacyclotetrahydrofolic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H25N5O6
|
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| Canonical SMILES |
C1=CC(=CC=C1CCCCC2=C(N=C(NC2=O)N)N)C(=O)NC(CCC(=O)O)C(=O)O
|
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| InChI |
1S/C20H25N5O6/c21-16-13(18(29)25-20(22)24-16)4-2-1-3-11-5-7-12(8-6-11)17(28)23-14(19(30)31)9-10-15(26)27/h5-8,14H,1-4,9-10H2,(H,23,28)(H,26,27)(H,30,31)(H5,21,22,24,25,29)/t14-/m0/s1
|
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| InChIKey |
LNUHUIPUTGDPDG-AWEZNQCLSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycinamide ribonucleotide formyltransferase (GART) | Target Info | Inhibitor | [1] |
| BioCyc | Purine nucleotides de novo biosynthesis | |||
| 5-aminoimidazole ribonucleotide biosynthesis | ||||
| Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate | ||||
| KEGG Pathway | Purine metabolism | |||
| One carbon pool by folate | ||||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | De novo purine biosynthesis | |||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | |||
| WikiPathways | One Carbon Metabolism | |||
| Metabolism of nucleotides | ||||
| Folate Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 2008 Sep 11;51(17):5441-8. | |||
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