Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R6FJ
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| Former ID |
DNC011502
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| Drug Name |
NORHARMANE
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| Synonyms |
9H-Pyrido[3,4-B]indole; Norharman; Norharmane; 244-63-3; beta-Carboline; 2,9-Diazafluorene; Carbazoline; 9H-Beta-carboline; 2-Azacarbazole; 9H-Pyrido(3,4-B)indole; .beta.-Carboline; Carbazoline (VAN); b-carboline; beta Carboline; 2H-Pyrido[3,4-b]indole; UNII-94HMA1I78O; CCRIS 6915; CHEBI:109895; EINECS 205-959-0; NSC 84417; BRN 0128414; MLS000069651; 94HMA1I78O; CHEMBL275224; AIFRHYZBTHREPW-UHFFFAOYSA-N; Norharman, 98%; SMR000058207; AK-25655; N-8720; N-8700; 244-66-6; SR-01000000213; 9h-; Prestwick_363; Norharmane, 98%; zlchem 7
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C11H8N2
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| Canonical SMILES |
C1=CC=C2C(=C1)C3=C(N2)C=NC=C3
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| InChI |
1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
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| InChIKey |
AIFRHYZBTHREPW-UHFFFAOYSA-N
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| CAS Number |
CAS 244-63-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
122166, 646046, 855536, 3134108, 5536206, 7980024, 8189408, 10321411, 10515297, 11364026, 11366588, 11369150, 11371642, 11375670, 11377312, 11448734, 11484172, 11488404, 11490557, 11493729, 11494946, 11537690, 12015776, 14843142, 22388129, 24897776, 26679360, 26746906, 29204446, 30134734, 32469833, 37423398, 43121816, 47217266, 47811249, 48259727, 48414245, 49748324, 49748325, 49857602, 50100962, 50103899, 50734380, 53787843, 56422412, 57315208, 81093147, 85088300, 85315305, 85789440
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| ChEBI ID |
CHEBI:109895
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [2] |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8222). | |||
| REF 2 | Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. | |||
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