Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0R3WG
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| Former ID |
DIB007666
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| Drug Name |
SILPERISONE HYDROCHLORIDE
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| Synonyms |
RGH-5002; SILA-336; Silperisone hydrochloride; 1-[(4-Fluorobenzyl)dimethylsilylmethyl]piperidine hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Spasm [ICD-11: MB47.3; ICD-10: R25.2; ICD-9: 728.85] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H25ClFNSi
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| Canonical SMILES |
C[Si](C)(CC1=CC=C(C=C1)F)CN2CCCCC2.Cl
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| InChI |
1S/C15H24FNSi.ClH/c1-18(2,13-17-10-4-3-5-11-17)12-14-6-8-15(16)9-7-14;/h6-9H,3-5,10-13H2,1-2H3;1H
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| InChIKey |
VGKGHWXDGBFJTP-UHFFFAOYSA-N
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| CAS Number |
CAS 140944-30-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium channel unspecific (NaC) | Target Info | Modulator | [2], [3] |
| KEGG Pathway | Dopaminergic synapse | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002660) | |||
| REF 2 | Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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